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HomeShopPremium PeptidesAnti-agingTesofensine
Tesofensine

Tesofensine

170,00$

description

Tesofensine is a centrally acting dopamine, norepinephrine, and serotonin reuptake inhibitor (DNRI/SNRI/SSRI) originally developed for neurodegenerative disease research. It is now widely studied for its potent effects on appetite suppression, energy metabolism, and body weight regulation in preclinical models of obesity and metabolic dysfunction.

Epigenetix Labs offers Tesofensine in high-purity, research-grade form. This compound is not approved for human or veterinary use and is intended exclusively for scientific and laboratory research.

10 Research-Based Reasons to Study Tesofensine

  • Inhibits DA, NE, and 5-HT reuptake in central nervous system
  • Reduces appetite and food cravings in obesity models
  • Enhances basal metabolic rate and lipid oxidation
  • Preserves lean body mass during caloric restriction
  • Improves insulin sensitivity and glucose metabolism
  • Increases locomotor activity and energy expenditure
  • Modulates hypothalamic appetite regulation pathways
  • Downregulates leptin and ghrelin in feeding studies
  • Reduces visceral adiposity in metabolic syndrome research
  • Studied as a non-stimulant alternative to classic anorectics
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SKU: N/A Categories:Anti-aging, Brain recovery, Energy recovery, Weight lossTag:New
Additional information

Additional information

Weight 0,006 kg
Dimensions 9,5 × 9,5 × 10 cm
Scientific Background

Tesofensine inhibits the presynaptic reuptake of dopamine (DA), norepinephrine (NE), and serotonin (5-HT), resulting in increased synaptic concentrations of these neurotransmitters. This leads to central appetite suppression, improved energy utilization, and enhanced lipid metabolism. Originally investigated for Parkinson’s and Alzheimer’s disease, Tesofensine has gained significant research interest in the treatment of obesity and metabolic syndrome due to its ability to reduce caloric intake and preserve lean mass during weight loss.

Key Research Findings

In rodent obesity models, Tesofensine reduced food intake by up to 40% and body weight by up to 20%, outperforming traditional appetite suppressants.
• A pivotal Phase II study (The Lancet) in humans demonstrated that Tesofensine induced significant weight loss with preservation of fat-free mass and improvements in insulin sensitivity.
• Preclinical data show increased dopaminergic tone, enhancing motivation and locomotor activity without the development of tolerance.
• Tesofensine reduces leptin levels, suggesting a reset in hypothalamic energy balance signaling.
• Neurochemical profiling reveals sustained monoamine elevation without serotonin syndrome or receptor downregulation in chronic use studies.

Research Applications

Tesofensine is being studied in the following research areas:

• Obesity and weight management models
• Metabolic syndrome and insulin resistance
• Hypothalamic neurotransmitter signaling
• Appetite regulation and feeding behavior
• Dopaminergic and noradrenergic modulation
• Neurodegenerative disease and cognitive stimulation

Purity & Manufacturing Standards

Tesofensine from Epigenetix Labs is:
Produced to research-grade standards
• Verified via HPLC and mass spectrometry with ≥98% purity
• Manufactured in ISO-certified, sterile laboratory facilities
• Supplied as a lyophilized powder or stabilized solution, depending on research format

Strict Legal Disclaimer

FOR RESEARCH USE ONLY. This product is not approved by the FDA and is not intended for human or veterinary use. It is not intended to diagnose, treat, cure, or prevent any disease. By purchasing Tesofensine from Epigenetix Labs, you confirm it will be used exclusively for scientific and laboratory research, handled by trained professionals in appropriate settings. Do not inject, ingest, or use in any non-research context.

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